Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 593, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.ijpharm.2020.120162
Keywords
Gold nanocage; Photothermal therapy; Triple-negative breast cancer; Heat shock protein; Targeted nano-system
Categories
Funding
- Natural Science Foundation of Zhejiang Province [Q18E030009]
- National Natural Science Foundation of China [81873018]
- Science and Technology Department of Zhejiang Province [LGF18H160037]
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The study successfully fabricated a microwave-triggered heat shock protein (HSP)-targeted gold nano-system that activates HSP70 overexpression in TNBC, significantly improving the targeting ability, tumor accumulation, and anti-tumor efficacy of cmHSP-AuNC.
Due to the lack of effective therapeutic targets and the passive delivery of a limited quantity of nanoparticles to the tumors, the photothermal conversion agents used in photothermal therapy (PTT) have not been effective in treating triple-negative breast cancer (TNBC). As a result, there is a need to improve the tumor-targeting ability of these photothermal conversion agents. To address this, a microwave-triggered heat shock protein (HSP)-targeted gold nano-system (cmHSP-AuNC), with a gold nanocage (AuNC) as a photothermal conversion agent and anti-HSP monoclonal antibody (cmHSP) as a targeting ligand, was fabricated. cmHSP-AuNC was characterized based on morphology, particle size, zeta potentials, absorption spectrum, and photothermal conversion ability. The expression of HSP70 in 4T1 cells after microwave irradiation was verified by western blotting, and the optimal treatment conditions to achieve the highest expression were determined. Both in vitro and in vivo results indicated that the induction through microwave irradiation could effectively activate the HSP70 overexpression in TNBC, thereby significantly improving the targeting ability, tumor accumulation and anti-tumor efficacy of cmHSP-AuNC. This study proposes a promising strategy for improving the targeting ability and therapeutic efficacy of PTT.
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