Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 593, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.ijpharm.2020.120112
Keywords
Nanoplatform; Photocatalytic reduction; pH-Sensitivity; Near-infrared irradiation; Chemo-photothermal therapy
Categories
Funding
- Guangzhou Science and Technology Project of Health [20181A010009]
- National Natural Science Foundation of China [11532003, 31670950]
- Primary Research & Developement Plan of Jiangsu Province [BE2019653]
- Advanced Catalysis and Green Manufacturing Collaborative Innovation Center [ACGM2016-06-27]
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The combination nanoplatform of graphene quantum dots and gold-silver nanoclusters shows significant efficacy in chemo-photothermal combination therapy for cancer cells, which can be modulated by adjusting pH and near-infrared irradiation for treatment.
Au nanoclusters, decorated with graphene quantum dots (GQDs), were obtained through photocatalytic reduction of AuCl43- by UV irradiation, and then cytarabine (Cyt) was loaded to the Au/GQDs via charge-dipole interactions. Mercaptopropionic acid (MPA) was anchored to the Cyt-loaded Au/GQDs through the formation of Au-S bond, which was further encapsulated by polyethyleneimine (PEI) via charge-dipole interactions. The delivery of Cyt from the quaternary complex (Au/GQDs/MPA/PEI) is pH-sensitive and can be modulated by near-infrared (NIR) irradiation. The results of cell viability test indicate that the developed nanoplatform can be used for chemo-photothermal combination therapy of cancer cells, and the efficacy of chemo-photothermal combination therapy is significantly higher than that of the single mode of photothermal therapy (PTT) or chemotherapy.
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