Journal
INTERNATIONAL JOURNAL OF NANOMEDICINE
Volume 15, Issue -, Pages 10257-10269Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S277046
Keywords
self-assembling peptide; hydrogel; angiogenesis; survival; retention
Funding
- National Natural Science Foundation of China [8197020412]
- Scientific Research Projects of Jiangsu Province Department of Health [H2018007]
- Wu Jieping Medical Foundation Basic Medical Scientific Research Project [320.6750.15153]
- Pre-research fund project of the second affiliated hospital of Soochow university [SDFEYBS1912]
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Ischemic diseases, especially in the heart and the brain, have become a serious threat to human health. Growth factor and cell therapy are emerging as promising therapeutic strategies; however, their retention and sustainable functions in the injured tissue are limited. Self-assembling peptide (SAP)-based hydrogels, mimicking the extracellular matrix, are therefore introduced to encapsulate and controllably release cells, cell-derived exosomes or growth factors, thus promoting angiogenesis and tissue recovery after ischemia. We will summarize the classification, composition and structure of SAPs, and the influencing factors for SAP gelation. Moreover, we will describe the functionalized SAPs, and the combinatorial therapy of cells, exosomes or growth factors with functionalized SAPs for angiogenic process as well as its advantage in immunogenicity and injectability. Finally, an outlook on future directions and challenges is provided.
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