4.7 Review

Pulsed Electromagnetic Field Stimulation in Osteogenesis and Chondrogenesis: Signaling Pathways and Therapeutic Implications

Related references

Note: Only part of the references are listed.
Article Health Care Sciences & Services

Effect of combined treatment with pulsed electromagnetic field stimulation and sclerostin monoclonal antibody on changes in bone metabolism and pedicle screw augmentation in rabbits with ovariectomy-induced osteoporosis

Guang Qian et al.

Summary: Both PEMF and Scl-Ab therapy can significantly improve bone mineral density and mechanical strength of pedicle screws in rabbits with postmenopausal osteoporosis. However, the combination of the two treatments yielded even better results, with potential clinical application value.

ANNALS OF PALLIATIVE MEDICINE (2021)

Article Engineering, Biomedical

Directionalities of magnetic fields and topographic scaffolds synergise to enhance MSC chondrogenesis

Cenk Celik et al.

Summary: The chondrogenic differentiation of MSCs is significantly influenced by the directionality of PEMF exposure, especially on random scaffolds. Results correlating with pFAK activation and YAP localization indicate different cellular responses of MSCs exposed to PEMF in different directions.

ACTA BIOMATERIALIA (2021)

Review Engineering, Biomedical

Advancing application of mesenchymal stem cell-based bone tissue regeneration

Fengqing Shang et al.

Summary: The utilization of regenerative biomaterials for bone repair requires not only efficacy and safety, but also cost-effectiveness and convenience. Understanding the roles of regenerative biomaterials and mesenchymal stem cells in new bone formation can potentially open new opportunities in the field of bone regeneration.

BIOACTIVE MATERIALS (2021)

Article Biotechnology & Applied Microbiology

Pulsed electromagnetic fields promote repair of focal articular cartilage defects with engineered osteochondral constructs

Robert M. Stefani et al.

BIOTECHNOLOGY AND BIOENGINEERING (2020)

Article Cell & Tissue Engineering

Pulsed electromagnetic fields potentiate the paracrine function of mesenchymal stem cells for cartilage regeneration

Dinesh Parate et al.

STEM CELL RESEARCH & THERAPY (2020)

Review Pharmacology & Pharmacy

Adenosinergic signalling in chondrogenesis and cartilage homeostasis: Friend or foe?

Rui Pinto-Cardoso et al.

BIOCHEMICAL PHARMACOLOGY (2020)

Article Orthopedics

Modulation of Notch1 signaling regulates bone fracture healing

Sanja Novak et al.

JOURNAL OF ORTHOPAEDIC RESEARCH (2020)

Review Cell & Tissue Engineering

Large-Scale Expansion of Human Mesenchymal Stem Cells

Muhammad Najib Fathi Bin Hassan et al.

STEM CELLS INTERNATIONAL (2020)

Review Endocrinology & Metabolism

Wnt modulation in bone healing

Drew Schupbach et al.

Review Cell Biology

L-type voltage-gated calcium channels in stem cells and tissue engineering

Yi-zhou Tan et al.

CELL PROLIFERATION (2019)

Review Cell Biology

Adult Stem Cells for Bone Regeneration and Repair

Maria Rosa Iaquinta et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2019)

Article Biology

A comprehensive overview on utilizing electromagnetic fields in bone regenerative medicine

Esmaeel Azadian et al.

ELECTROMAGNETIC BIOLOGY AND MEDICINE (2019)

Review Orthopedics

Biophysical stimulation of bone and cartilage: state of the art and future perspectives

Leo Massari et al.

INTERNATIONAL ORTHOPAEDICS (2019)

Review Cell Biology

The roles of signaling pathways in bone repair and regeneration

Maryam Majidinia et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2018)

Article Cell & Tissue Engineering

Magnitude-dependent and inversely-related osteogenic/chondrogenic differentiation of human mesenchymal stem cells under dynamic compressive strain

Christopher B. Horner et al.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2018)

Article Biochemistry & Molecular Biology

Pulsed electromagnetic field induces Ca2+-dependent osteoblastogenesis in C3H10T1/2 mesenchymal cells through the Wnt-Ca2+/Wnt-beta-catenin signaling pathway

Shaoyu Wu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Review Physiology

PHARMACOLOGY OF ADENOSINE RECEPTORS: THE STATE OF THE ART

Pier Andrea Borea et al.

PHYSIOLOGICAL REVIEWS (2018)

Article Genetics & Heredity

Genetic ablation of adenosine receptor A3 results in articular cartilage degeneration

Ruzanna Shkhyan et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2018)

Article Multidisciplinary Sciences

Endogenous adenosine maintains cartilage homeostasis and exogenous adenosine inhibits osteoarthritis progression

Carmen Corciulo et al.

NATURE COMMUNICATIONS (2017)

Article Pathology

Effects of Electromagnetic Stimulation on Osteogenic Differentiation of Human Mesenchymal Stromal Cells Seeded onto Gelatin Cryogel

E. Saino et al.

INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY (2017)

Article Cell & Tissue Engineering

Intraoperative delivery of the Notch ligand Jagged-1 regenerates appendicular and craniofacial bone defects

Daniel W. Youngstrom et al.

NPJ REGENERATIVE MEDICINE (2017)

Review Anatomy & Morphology

Role of Mesenchymal Stem Cells in Bone Regenerative Medicine: What Is the Evidence?

Ahmad Oryan et al.

CELLS TISSUES ORGANS (2017)

Review Pharmacology & Pharmacy

Pathological overproduction: the bad side of adenosine

Pier Andrea Borea et al.

BRITISH JOURNAL OF PHARMACOLOGY (2017)

Review Cell Biology

Mesenchymal Stem Cells Ageing: Targeting the Purinome to Promote Osteogenic Differentiation and Bone Repair

J. B. Noronha-Matos et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2016)

Review Orthopedics

Mesenchymal stromal cells for cartilage repair in osteoarthritis

M. K. Mamidi et al.

OSTEOARTHRITIS AND CARTILAGE (2016)

Review Pharmacology & Pharmacy

Adenosine as a Multi-Signalling Guardian Angel in Human Diseases: When, Where and How Does it Exert its Protective Effects?

Pier Andrea Borea et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2016)

Review Cell Biology

p38 MAPK Signaling in Osteoblast Differentiation

Eddie Rodriguez-Carballo et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2016)

Article Biochemistry & Molecular Biology

Polymodal Transient Receptor Potential Vanilloid (TRPV) Ion Channels in Chondrogenic Cells

Csilla Szucs Somogyi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)

Article Immunology

CD73 Plays a Protective Role in Collagen-Induced Arthritis

Pavel Chrobak et al.

JOURNAL OF IMMUNOLOGY (2015)

Article Medicine, General & Internal

Osteoarthritis

S. Glyn-Jones et al.

LANCET (2015)

Review Cell & Tissue Engineering

Bottlenecks in the Efficient Use of Advanced Therapy Medicinal Products Based on Mesenchymal Stromal Cells

Natalia Escacena et al.

STEM CELLS INTERNATIONAL (2015)

Article Cell & Tissue Engineering

Electromagnetic fields counteract IL-1β activity during chondrogenesis of bovine mesenchymal stem cells

Alessia Ongaro et al.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2015)

Article Engineering, Biomedical

Jagged1 immobilization to an osteoconductive polymer activates the Notch signaling pathway and induces osteogenesis

Michael I. Dishowitz et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2014)

Review Endocrinology & Metabolism

Adenosine and bone metabolism

Aranzazu Mediero et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2013)

Article Pharmacology & Pharmacy

Expression and functional role of adenosine receptors in regulating inflammatory responses in human synoviocytes

K. Varani et al.

BRITISH JOURNAL OF PHARMACOLOGY (2010)

Article Cell & Tissue Engineering

Adipose Tissue Derived Stem Cells Secretome: Soluble Factors and Their Roles in Regenerative Medicine

Antonio J. Braga Osorio Gomes Salgado et al.

Current Stem Cell Research & Therapy (2010)

Review Medicine, General & Internal

Mesenchymal stem cells and cartilage in situ regeneration

W. Richter

JOURNAL OF INTERNAL MEDICINE (2009)

Article Critical Care Medicine

Electrical treatment of tibial non-union: a prospective, randomised, double-blind trial

RB Simonis et al.

INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED (2003)

Article Pharmacology & Pharmacy

Effect of low frequency electromagnetic fields on A2A adenosine receptors in human neutrophils

K Varani et al.

BRITISH JOURNAL OF PHARMACOLOGY (2002)