Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/ijms22010417
Keywords
dentistry; dental base resin; 3D printing; poly(methyl methacralyate); zwitterion; oral salivary biofilm; durability
Funding
- Korea Medical Device Development Fund - Korea government (the Ministry of Science and ICT) [202011D04]
- Korea Medical Device Development Fund - Korea government (Ministry of Trade, Industry and Energy) [202011D04]
- Korea Medical Device Development Fund - Korea government (Ministry of Health &Welfare, Republic of Korea) [202011D04]
- Korea Medical Device Development Fund - Korea government (Ministry of Food and Drug Safety) [202011D04]
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The study found that adding MPC or SB to 3D-printed PMMA specimens significantly reduced bacterial and biofilm adhesion, with minimal degradation in mechanical properties that still met international standards, and resistance to biofilm was maintained after hydrothermal fatigue testing.
Poly(methyl methacralyate) (PMMA) has long been used in dentistry as a base polymer for dentures, and it is recently being used for the 3D printing of dental materials. Despite its many advantages, its susceptibility to microbial colonization remains to be overcome. In this study, the interface between 3D-printed PMMA specimens and oral salivary biofilm was studied following the addition of zwitterionic materials, 2-methacryloyloxyethyl phosphorylcholine (MPC) or sulfobetaine methacrylate (SB). A significant reduction in bacterial and biofilm adhesions was observed following the addition of MPC or SB, owing to their protein-repellent properties, and there were no significant differences between the two test materials. Although the mechanical properties of the tested materials were degraded, the statistical value of the reduction was minimal and all the properties fulfilled the requirements set by the International Standard, ISO 20795-2. Additionally, both the test materials maintained their resistance to biofilm when subjected to hydrothermal fatigue, with no further deterioration of the mechanical properties. Thus, novel 3D-printable PMMA incorporated with MPC or SB shows durable oral salivary biofilm resistance with maintenance of the physical and mechanical properties.
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