Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/ijms22010216
Keywords
macrophages; foam cells; RhoA; atherosclerosis; inflammation
Funding
- Polish Ministry of National Defense project Kociuszko [5508/2017/DA]
Ask authors/readers for more resources
The development, progression, or stabilization of atherosclerotic plaques depend on the role of pro-inflammatory and anti-inflammatory macrophages. Targeting macrophages and the RhoA pathway could potentially inhibit inflammation, promote tissue remodeling, and contribute to the resolution of atherosclerosis.
The development, progression, or stabilization of the atherosclerotic plaque depends on the pro-inflammatory and anti-inflammatory macrophages. The influx of the macrophages and the regulation of macrophage phenotype, inflammatory or anti-inflammatory, are controlled by the small GTPase RhoA and its downstream effectors. Therefore, macrophages and the components of the RhoA pathway are attractive targets for anti-atherosclerotic therapies, which would inhibit macrophage influx and inflammatory phenotype, maintain an anti-inflammatory environment, and promote tissue remodeling and repair. Here, we discuss the recent findings on the role of macrophages and RhoA pathway in the atherosclerotic plaque formation and resolution and the novel therapeutic approaches.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available