Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/ijms22031026
Keywords
microbiota; hematological malignancies; bacterial metabolites; chemotherapy; allogeneic stem cell transplantation; autologous stem cell transplant; CAR-T cell therapy
Funding
- Ministry of Business and Knowledge of the Government of Catalonia [2019-BP-00204]
- European Union [801370, 754550]
- La Caixa Foundation [CP042702]
- Instituto de Salud Carlos III
- Spanish Ministry of Health (FIS) [PI18/00775, PI19/00669, ICI19/00025, CONCORD-023]
- Fondo Europeo de Desarrollo Regional (FEDER)
- AGAUR [2017SGR00792]
- Generalitat de Catalunya
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Hematological malignancies are a heterogeneous group of neoplasms that affect the blood, bone marrow, and lymph nodes, originating from uncontrolled growth of hematopoietic and lymphoid cells. The gut microbiota has been implicated in the genesis and progression of many diseases beyond the gut, largely through the small molecules they produce.
Hematological malignancies, including multiple myeloma, lymphoma, and leukemia, are a heterogeneous group of neoplasms that affect the blood, bone marrow, and lymph nodes. They originate from uncontrolled growth of hematopoietic and lymphoid cells from different stages in their maturation/differentiation and account for 6.5% of all cancers around the world. During the last decade, it has been proven that the gut microbiota, more specifically the gastrointestinal commensal bacteria, is implicated in the genesis and progression of many diseases. The immune-modulating effects of the human microbiota extend well beyond the gut, mostly through the small molecules they produce. This review aims to summarize the current knowledge of the role of the microbiota in modulating the immune system, its role in hematological malignancies, and its influence on different therapies for these diseases, including autologous and allogeneic stem cell transplantation, chemotherapy, and chimeric antigen receptor T cells.
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