Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 21, Issue 23, Pages -Publisher
MDPI
DOI: 10.3390/ijms21239020
Keywords
prostacyclin; thromboxane; prostaglandin; platelets
Funding
- European Regional Development Fund (EFRE) [85036717]
Ask authors/readers for more resources
Prostanoids are bioactive lipid mediators and take part in many physiological and pathophysiological processes in practically every organ, tissue and cell, including the vascular, renal, gastrointestinal and reproductive systems. In this review, we focus on their influence on platelets, which are key elements in thrombosis and hemostasis. The function of platelets is influenced by mediators in the blood and the vascular wall. Activated platelets aggregate and release bioactive substances, thereby activating further neighbored platelets, which finally can lead to the formation of thrombi. Prostanoids regulate the function of blood platelets by both activating or inhibiting and so are involved in hemostasis. Each prostanoid has a unique activity profile and, thus, a specific profile of action. This article reviews the effects of the following prostanoids: prostaglandin-D-2 (PGD(2)), prostaglandin-E-1, -E-2 and E-3 (PGE(1), PGE(2), PGE(3)), prostaglandin F-2 alpha (PGF(2 alpha)), prostacyclin (PGI(2)) and thromboxane-A(2) (TXA(2)) on platelet activation and aggregation via their respective receptors.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available