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The Complex Interplay between Endocannabinoid System and the Estrogen System in Central Nervous System and Periphery

Journal

Publisher

MDPI
DOI: 10.3390/ijms22020972

Keywords

endocannabinoid system; estrogens; central nervous system; reproduction; cancer

Funding

  1. Miur, Prin 2017 [20175MT5EM]
  2. University of Salerno [ORSA188304, ORSA191889]
  3. FFABR from MIUR

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The article discusses the interaction between the endocannabinoid system and estrogen system at both central and peripheral levels, with a focus on the central nervous system, reproduction, and cancer.
The endocannabinoid system (ECS) is a lipid cell signaling system involved in the physiology and homeostasis of the brain and peripheral tissues. Synaptic plasticity, neuroendocrine functions, reproduction, and immune response among others all require the activity of functional ECS, with the onset of disease in case of ECS impairment. Estrogens, classically considered as female steroid hormones, regulate growth, differentiation, and many other functions in a broad range of target tissues and both sexes through the activation of nuclear and membrane estrogen receptors (ERs), which leads to genomic and non-genomic cell responses. Since ECS function overlaps or integrates with many other cell signaling systems, this review aims at updating the knowledge about the possible crosstalk between ECS and estrogen system (ES) at both central and peripheral level, with focuses on the central nervous system, reproduction, and cancer.

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