Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/ijms22020627
Keywords
anoikis; anchorage-independent growth; metastasis; apoptosis; noncoding RNA; microRNA; long noncoding RNA; cancer
Funding
- National Research Foundation of Korea (NRF) - Ministry of Education [2017R1D1A3B03035662, 2019R1A6A1A11036849]
- National Research Foundation of Korea (NRF) - Korea government (MSIT) [2019R1A2C1089710]
- National Research Foundation of Korea [2019R1A6A1A11036849, 2019R1A2C1089710, 2017R1D1A3B03035662] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Cancer metastasis is a complex process involving cancer cells acquiring the abilities of anoikis resistance and anchorage-independent cell growth. Noncoding RNAs play a crucial role in regulating cellular events and pathways, contributing to cancer aggressiveness. Researchers are exploring the potential of ncRNA-based therapy for more effective strategies against cancer.
Cancer is a global health concern, and the prognosis of patients with cancer is associated with metastasis. Multistep processes are involved in cancer metastasis. Accumulating evidence has shown that cancer cells acquire the capacity of anoikis resistance and anchorage-independent cell growth, which are critical prerequisite features of metastatic cancer cells. Multiple cellular factors and events, such as apoptosis, survival factors, cell cycle, EMT, stemness, autophagy, and integrins influence the anoikis resistance and anchorage-independent cell growth in cancer. Noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), are dysregulated in cancer. They regulate cellular signaling pathways and events, eventually contributing to cancer aggressiveness. This review presents the role of miRNAs and lncRNAs in modulating anoikis resistance and anchorage-independent cell growth. We also discuss the feasibility of ncRNA-based therapy and the natural features of ncRNAs that need to be contemplated for more beneficial therapeutic strategies against cancer.
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