Evaluation of Nanotargeted 111In-Cyclic RGDfK-Liposome in a Human Melanoma Xenotransplantation Model

Nanotargeted liposomes may be modified with targeting peptide on the surface of a prepared liposome to endow specificity and elevate targeting efficiency. The aim of this study was to develop a radioactive targeted nanoparticle, the In-111-cyclic RGDfK-liposome, and its advantage of recognizing the alpha(V)beta 3 integrin was examined. The cyclic RGDfK modified liposomes were demonstrated the ability to bind the alpha(V)beta 3 integrin expressed on the surface of human melanoma cell in vitro and in vivo. The effects of the cyclic RGDfK-liposome on the functioning of phagocytes was also examined, showing no considerable negative effects on the engulfment of bacteria and the generation of reactive oxygen species. Based upon these findings, the cyclic RGDfK- liposome is said to be a promising agent for tumor imaging.

Automated summary

Nanotargeted liposomes modified with targeting peptides show increased specificity and efficiency in tumor targeting. The development of In-111-cyclic RGDfK-liposome demonstrated the ability to recognize alpha(V)beta 3 integrin and has potential for tumor imaging applications. Additionally, it showed no significant negative effects on phagocyte function, making it a promising agent for tumor imaging.