Journal
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
Volume 47, Issue 3, Pages -Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/ijmm.2021.4846
Keywords
astragaloside IV; epithelial-mesenchymal transformation; cancer; molecular mechanisms; chemosensitivity
Categories
Funding
- Tianjin Science & Technology Plan Projects [17ZXMFSY00190]
- Tianjin Traditional Chinese Medicine Research Project, Tianjin health and family planning commission [2017003]
- National Natural Science Foundation of China [81403220]
Ask authors/readers for more resources
Astragaloside IV (AS-IV) has been shown to play a vital role in inhibiting tumor growth and metastasis, promoting apoptosis of tumor cells, and controlling various signaling pathways. This review provides new perspectives on the functions of AS-IV as an adjuvant treatment in cancer chemotherapy.
Radix Astragali (RA) is widely used in traditional Chinese medicine (TCM), and astragaloside IV (AS-IV) is the most critical component of RA. Previous studies have demonstrated that AS-IV exerts effects on the myocardium, nervous system and endocrine system, among others. In the present review article, data from studies conducted over the past 20 years were collated, which have evaluated the effects of AS-IV on tumors. The mechanisms of action of AS-IV on malignant cells both in vivo and in vitro were summarized and it was demonstrated that AS-IV plays a vital role, particularly in inhibiting tumor growth and metastasis, promoting the apoptosis of tumor cells, enhancing immune function and preventing drug resistance. Moreover, AS-IV controls several epithelial-mesenchymal transformation (EMT)-related and autophagy-related pathways, such as the phosphoinositide-3-kinase (PI3K)/protein kinase B (AKT), Wnt/beta-catenin, mitogen-activated protein kinase (MAPK)/extracellular regulated protein kinase (ERK) and transforming growth factor-beta (TGF-beta)/SMAD signaling pathways, which are commonly affected in the majority of tumors. The present review provides new perspectives on the functions of AS-IV and its role as an adjuvant treatment in cancer chemotherapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available