Journal
INTERNATIONAL JOURNAL OF MEDICAL ROBOTICS AND COMPUTER ASSISTED SURGERY
Volume 17, Issue 2, Pages -Publisher
WILEY
DOI: 10.1002/rcs.2235
Keywords
amyotrophic lateral sclerosis; MRI‐ guided therapy; spine
Categories
Funding
- Royal Society Wolfson Fellowship
- NIH Benchto-Bedside Award
- AU-UGA InterInstitutional Seed Funding
- American Society for Quality
- National Science Foundation (NSF) I-Corps Team Grant [1617340]
- NSF REU site program [1359095]
- NIH Center for Interventional Oncology Grant
- Clinical and Translational Science Award Program of the NIH National Center for Advancing Translational Sciences [UL1TR000454]
- Directorate For Engineering
- Div Of Engineering Education and Centers [1359095] Funding Source: National Science Foundation
- Div Of Industrial Innovation & Partnersh
- Directorate For Engineering [1617340] Funding Source: National Science Foundation
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A robotic system was developed to assist in MRI-guided percutaneous injections to the spinal cord, with mean targeting errors of 0.48 and 2.84 mm in phantom models and swine cadavers, respectively. The targeting procedure duration is approximately 60 min, with an extra 10 min for each additional injection, enabling a simplified workflow for MRI-guided spinal therapy without affecting imaging quality.
Background Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with no cure and limited treatment options. Recent studies have shown that delivering cellular therapeutics to the ventral horn of the spinal cord can effectively halt neurodegeneration associated with ALS in small animal models. Methods We developed a robotic system that assists with MRI-guided percutaneous injections to the spinal cord. The needle positioning robot consists of two linear axes with motorised translational sleds for two-degree-of-freedom (2-DOF) needle translation and a radial template for 2-DOF discrete rotation. Results The robot's targeting capability, evaluated using phantom models and swine cadavers, showed mean targeting errors of 0.48 and 2.84 mm, respectively. The duration of the targeting procedure is approximately 60 min, with an extra 10 min for each additional injection. Conclusions The presented robot does not affect imaging quality during MRI-guided procedures, and it enables a simplified workflow for MRI-guided spinal therapy.
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