Use of metformin earlier in pregnancy predicts supplemental insulin therapy in women with gestational diabetes

The use of metformin in gestational diabetes is safe and effective, yet some women require additional insulin therapy to achieve glycaemic targets. We found a significant association between earlier gestational age at initiation of metformin therapy and the necessity for supplemental insulin in women treated with metformin during pregnancy. (C) 2016 Elsevier Ireland Ltd. All rights reserved.