Journal
INTERNATIONAL JOURNAL OF HEMATOLOGY
Volume 113, Issue 1, Pages 24-33Publisher
SPRINGER JAPAN KK
DOI: 10.1007/s12185-020-03053-y
Keywords
Disseminated intravascular blood coagulation; Fibrinolysis; Coagulopathy; Endothelial cell
Categories
Funding
- Promotion and Mutual Aid Corporation for Private Schools of Japan
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Disseminated intravascular coagulation (DIC) is a common and life-threatening complication in sepsis, and recent advances in understanding the pathophysiology have improved early diagnosis accuracy, although progress in treatment remains limited.
Disseminated intravascular coagulation (DIC) is a common and life-threatening complication in sepsis. Sepsis-associated DIC is recognized as the systemic activation in coagulation with suppressed fibrinolysis that leads to organ dysfunction in combination with systemic intravascular inflammation. In this process, thrombin contributes a key role in connecting both coagulation and inflammation. Endothelial injury, a result of sepsis, causes DIC due to the effect of multiple activated factors that include neutrophils, platelets, and damage-associated molecular patterns. Recent advances in the understanding of pathophysiology have made it possible to diagnose sepsis-associated DIC at earlier timing with better accuracy. However, progress in the treatment is still limited, and new therapeutics for sepsis-associated DIC are needed.
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