Journal
BMC PLANT BIOLOGY
Volume 15, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s12870-014-0378-0
Keywords
Glyphosate; Gcn2; Transcriptomic; Shikimate; Translation; Herbicide
Categories
Funding
- Universidad Politecnica de Valencia [PAID2011-16]
- Ministerio Espanol de Ciencia y Tecnologia [BFU2011-22526, AGL-2010-18621]
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Background: The increased selection pressure of the herbicide glyphosate has played a role in the evolution of glyphosate-resistance in weedy species, an issue that is becoming a threat to global agriculture. The molecular components involved in the cellular toxicity response to this herbicide at the expression level are still unidentified. Results: In this study, we identify the protein kinase GCN2 as a cellular component that fosters the action of glyphosate in the model plant Arabidopsis thaliana. Comparative studies using wild-type and gcn2 knock-out mutant seedlings show that the molecular programme that the plant deploys after the treatment with the herbicide, is compromised in gcn2. Moreover, gcn2 adult plants show a lower inhibition of photosynthesis, and both seedlings and adult gcn2 plants accumulate less shikimic acid than wild-type after treatment with glyphosate. Conclusions: These results points to an unknown GCN2-dependent factor involved in the cascade of events triggered by glyphosate in plants. Data suggest either that the herbicide does not equally reach the target-enzyme in a gcn2 background, or that a decreased flux in the shikimate pathway in a gcn2 plants minimize the impact of enzyme inhibition.
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