Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 167, Issue -, Pages 182-192Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2020.11.168
Keywords
Marine polysaccharide; Kangfuxin; Multifunctional composite sponges; Wound healing
Funding
- National Natural Science Foundation of China [31900957]
- Shandong Provincial Natural Science Foundation [ZR2019QC007]
- Innovation and Technology Program for the Excellent Youth Scholars of Higher Education of Shandong province [2019KJE015]
- China Postdoctoral Science Foundation [2019M652326]
- Scientific Research Foundation of Qingdao University [DC1900009689]
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The development of multifunctional composite sponges incorporating traditional Chinese medicine Kangfuxin into alginate/carboxymethyl chitosan shows great potential for promoting wound healing, with properties such as suitable water vapor transmittance, antibacterial behavior, cytocompatibility, and rapid hemostasis. In a rat full-thickness wounds model, the composite sponge significantly facilitates wound closure compared to conventional wound dressings.
Conventional wound-dressing materials with structural and functional deficiencies are not effective in promoting wound healing. The development of multifunctional wound dressings is emerging as a promising strategy to accelerate blood coagulation, inhibit bacterial infection, and trigger full-thickness wound into a regenerative process. Herein, multifunctional composite sponges were developed by incorporation of traditional Chinese medicine Kangfuxin (KFX) into alginate (AG)/carboxymethyl chitosan (CMC) via green crosslinking, electrostatic interaction, and freeze-drying methods. It is demonstrated that the AG/CMC/KFX (ACK) sponges exhibit a highly interconnected and porous structure, suitable water vapor transmittance, excellent elastic properties, antibacterial behavior, cytocompatibility, and rapid hemostasis. Further, in a rat full-thickness wounds model, the ACK sponge containing 10% KFX (ACK-10) significantly facilitates wound closure compared to the AC group and ACK sponge containing 5% and 15% KFX. Thus, the multifunctional ACK-10 composite sponge has great promise for the application of full-thickness wound healing. (C) 2020 Published by Elsevier B.V.
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