Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 164, Issue -, Pages 3250-3258Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2020.08.190
Keywords
Cellulose sponge; Curcumin-beta-cyclodextrin inclusion complex; Wound dressing
Funding
- Royal Golden Jubilee Ph.D. scholarship, Thailand Research Fund (TRF) [PHD/0043/2559]
- Thailand Institute of Scientific and Technological Research (TISTR) through Scientific and Technological Instruments Center (STIC), Mae Fah Luang University
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In this research, the cellulose sponges with curcumin-beta ss-cyclodextrin inclusion complex (CMx) and chitosan (CS) were fabricated for use as wound dressings. 1-Allyl-3-methylimidazolium chloride (AMIMCl) ionic liquid as a green solvent was used for the fabrication of cellulose sponges. Due to the low aqueous solubility and low bioavailability of curcumin, cyclodextrins (CDs) were applied and complexed with curcumin to obtain CMx. In addition, CS was incorporated in the cellulose sponges to improve the antibacterial activity of sponges. Attenuated total reflection-Fourier transform infrared (ATR-FTIR) analysis, morphological appearances, mechanical properties, water retention and weight loss, release behaviors, antibacterial activity, indirect cytotoxicity, cell attachment, and cell proliferation of the CMx/CS-loaded cellulose sponges were investigated. From the results, the cellulose sponges showed a porous structure. The incorporation of CMx and CS improved the mechanical properties when compared to the neat cellulose sponges. Moreover, the addition of CS into the cellulose sponges exhibited antibacterial activity against E. coli and S. aureus. Furthermore, the indirect cytotoxicity of the CMx/CS-loaded cellulose sponges was non-toxic and compatible with NCTC L929 and NHDF cells. Consequently, the CMx/CS-loaded cellulose sponges might be good candidates for use as wound dressing materials for the treatment of wound, especially chronic wound. (C) 2020 Elsevier B.V. All rights reserved.
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