Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 164, Issue -, Pages 2818-2830Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2020.08.170
Keywords
Agarose/kappa-carrageenan lend; Cryphaea heteromalla bryophyte; Wound healing
Funding
- European Social Assets Sicilia 2020 - Rafforzare l'occupabilita nel sistema R&S e la nascita di Spin Off di ricerca in Sicilia (P.O. FSE 2014/2020 Project) [CUP: G77B17000220009]
Ask authors/readers for more resources
Hydrogels for complex and chronic wound dressings must be conformable, absorb and retain wound exudates and maintain hydration. They can incorporate and release bioactive molecules that can accelerate the healing process. Wound dressings have to be in contact with the wound and epidermis, even for long periods, without causing adverse effects. Hydrogel dressing formulations based on biopolymers derived from terrestrial or marine flora can be relatively inexpensive and well tolerated. In the present article hydrogel films composed by agarose (1.0wt%),kappa-carrageenan at three different concentrations (0.5, 1.0 and 1.5wt%) and glycerol (3.0wt%) were prepared without recourse to crosslinking agents, and characterized for their mechanical properties, morphology, swelling and erosion behavior. The films resulted highly elastic and able to absorb and retain large amounts of fluids without losing their integrity. One of the films was loaded with the aqueous extract from Cryphaea heteromalla (Hedw.) D. Mohr for its antioxidant properties. Absence of cytotoxicity and ability to reduce the oxidative stress were demonstrated on NIH-3T3 fibroblast cell cultures. These results encourage further biological evaluations to assess their impact on the healing process. (C) 2020 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available