Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 165, Issue -, Pages 1468-1474Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2020.10.046
Keywords
Soy protein isolate; Cellulose nanocrystal; Curcumin; Complex nanoparticle
Funding
- Department of Education of Zhejiang province [Y201942515]
- Fundamental Research Funds for Zhejiang Provincial Universities and Research Institutes [2019J00004]
- National Natural Science Foundation of China [21476212]
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In this study, we developed novel complex nanoparticles as carriers for curcumin (Cur) delivery by using soy protein isolate (SPI) and cellulose nanocrystals (CNC) as polymer matrices. We found that the SPI-to-CNCmass ratio influenced the stability and physical properties of the SPI-CNC complex nanoparticles. Moreover, SPI-CNC complex nanoparticles had a relatively small size (197.7 +/- 0.2 nm) and lowpolydispersity index (0.14) at a 6:1 mass ratio. The nanosystem was relatively stable at different pH values (3-9), temperatures (30-90 degrees C), and salt concentrations (0-40 mmol/L). Furthermore, the complex nanoparticles exhibited a high encapsulation efficiency (88.3%) and sustained release during simulated gastrointestinal digestion. Therefore, SPI-CNC complex nanoparticles are a promising delivery system for hydrophobic bioactive compounds. (C) 2020 Elsevier B.V. All rights reserved.
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