Journal
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
Volume 57, Issue 3, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.ijantimicag.2021.106277
Keywords
Vaginal dysbiosis; Vaginal microbiota transplantation; VMT; Probiotic combination; High-throughput sequencing analysis
Funding
- National Natural Science Foundation of China [82060638, 81873659, 91639106]
- double 10-thousand plan of Jiangxi Province (innovation and technology professionals as the high-end talent)
- Academic and technical leaders of major disciplines in Jiangxi Province [20194BCJ22032]
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Vaginal dysbiosis, characterized by disturbed vaginal microbiota, is associated with gynaecological diseases, requiring effective therapeutic agents with VMT or probiotic combination showing promise in reducing inflammation and restoring microbiota balance to prevent recurrence.
Vaginal dysbiosis is characterised by a disturbed vaginal microbiota and is associated with various gynaecological diseases. Owing to its high recurrence rate, there is an urgent need for the development of effective therapeutic agents. In the present study, a vaginal dysbiosis model was developed to study the effect of vaginal microbiota transplantation (VMT) or probiotic combination (containing Lactobacillus helveticus, Lactobacillus crispatus, Lactobacillus acidophilus, Lactobacillus gasseri and Lactobacillus salivarius) on vaginal dysbiosis. Our results indicated that VMT or probiotic combination significantly reduced bacterial induced inflammation (infiltration of neutrophils, lymphocytes and monocytes) in the uterine wall and the enrichment of pro-inflammatory cytokines [interleukin-1 beta (IL-1 beta) and tumour necrosis factor-alpha (TNF alpha)] in vaginal tissue, and restored the disturbed vaginal microbiota to normal levels (increased numbers of Lactobacillus and decreased numbers of Enterobacter and Enterococcus), thus it should be beneficial for avoiding the recurrence of vaginal dysbiosis. Therefore, VMT or probiotic combination might be an effective agent for the treatment of bacterial-induced vaginosis. (C) 2021 Elsevier Ltd and International Society of Antimicrobial Chemotherapy. All rights reserved.
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