An overview on the progress and development on the palladium catalyzed direct cyanation

Generation of the positive CN ion and the corresponding direct cyanation are both extremely important for cyanation of aromatic compounds. Hereby, we would like to report the simultaneous use of the new Pd nano-catalyst as well as the three types of the N-arylsulfonyl cyanamides (A, B and C) as potent reagents for the in situ generation of the positive CN ion for the direct cyanation of phenylboronic acids in acetonitrile at reflux conditions.

Automated summary

The simultaneous use of a new Pd nano-catalyst and three types of N-arylsulfonyl cyanamides enables the in situ generation of the positive CN ion for direct cyanation of phenylboronic acids in acetonitrile at reflux conditions, providing an important strategy for the cyanation of aromatic compounds.