Journal
INORGANIC CHEMISTRY COMMUNICATIONS
Volume 122, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.inoche.2020.108245
Keywords
Colorimetric probe; Cyanide (CN-); Dicyanomethylene-4H-pyran; Fluorescent turn-on probe; Intramolecular Charge Transfer; Near-infrared emission
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Funding
- National Natural Science Foundation of China [21907023, 21001040, U1304202, U1604124]
- National Natural Science Foundation of Henan Province [U1304202, U1604124]
- Science and Technology Department of Henan Province [182300410183, 162300410011, 162300410236, 152102210343]
- Education Department of Henan Province [19A150001, 15B150016, 15HASTIT002]
- Fundamental Research Funds for the Universities of Henan Province [NSFRF180323]
- Foundation of Henan Polytechnic University [T2018-3, J2015-4]
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A novel dicyanomethylene-4H-pyran-based sensor bearing 2-thiophenecarbonyl as a masking group was established for the detection of cyanide anions. Upon the addition of cyanide, sensor 1 manifested a near-infrared emission band at 717 nm, with an extremely large red-shift (similar to 180 nm) in the absorption spectrum. It also showed an obvious color change from yellow to green. Sensor 1 was used to sensitively measure CN- with low detection limit of 1.44 mu M. The stoichiometric ratio between probe and CN- were determined as 1:1, with the association constant of 7.87 x 10(2) M-1. The reaction mechanism was investigated by ESI-MS, H-1 NMR, HPLC, and density functional theory methods. Results indicate that the nucleophilicity of the cyanide catalyzes the elimination of 2-thiophenecarbonyl, which strengthens the intramolecular charge transfer effect of the dicyanomethylene-4H-pyran fluorophore. Furthermore, sensor 1 was found to be efficient in detecting cyanide in the intracellular region of MCF-7 cells.
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