Two nickel (II) complexes of 2-acetylpyrazine thiosemicarbazones: Synthesis, crystal structures and biological evaluation

In this article, two nickel complexes of 2-acetylpyrazine thiosemicarbazone formulated as [Ni(L-1)(2)]center dot CH3OH (1) and [Ni-2(L-2)(3)]ClO4 center dot C2H5OH (2) (HL1 = 2-acetylpyrazine N-4-methylthiosemicarbazone, HL2 = 2-acetylpyrazine N-4-dimethylthiosemicarbazone), have been synthesized and structurally characterized. The antibacterial activities of the two complexes and ligands were studied. It is found that the ligand HL2 and its corresponding complex displayed effective antimicrobial activity against the tested bacterial. Besides, the growth inhibition assays indicated that complex 2 and the two proligands are capable of showing inhibitory activity against the human hepatocellular carcinoma HepG2 cells, and the subsequent toxicity study on normal QSG7701cells showed that complex 2 has the highest tumor cells selectivity, and its IC50 values is 7.21 times higher than in HepG2 cells.

Automated summary

The article describes the synthesis and characterization of two nickel complexes of 2-acetylpyrazine thiosemicarbazone, and studies their antibacterial activities. It was found that one of the complexes showed effective antimicrobial activity against tested bacteria, and that complex 2 exhibited inhibitory activity against human hepatocellular carcinoma HepG2 cells. Additionally, toxicity study showed that complex 2 had the highest tumor cell selectivity.