Differential serological and neutralizing antibody dynamics after an infection by a single SARS-CoV-2 strain

Background We report here the case of two coworkers infected by the same SARS-CoV-2 strain, presenting two different immunological outcomes. Case One patient presented a strong IgG anti-receptor-binding domain immune response correlated with a low and rapidly decreasing titer of neutralizing antibodies. The other patient had a similar strong IgG anti-receptor-binding domain immune response but high neutralizing antibody titers. Discussion and conclusion Thus, host individual factors may be the main drivers of the immune response varying with age and clinical severity.

Automated summary

Two coworkers were infected by the same SARS-CoV-2 strain with different immunological outcomes. One had low and rapidly decreasing neutralizing antibody titers, while the other had high titers. Host individual factors may be the main drivers of the varying immune responses.