Journal
IMMUNITY
Volume 53, Issue 6, Pages 1245-+Publisher
CELL PRESS
DOI: 10.1016/j.immuni.2020.11.004
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Funding
- Russian Science Foundation [20-15-00395]
- Ministry of Science and Higher Education of the Russian Federation [075-15-2019-1789, 075-15-2019-1660]
- Russian Foundation for Basic Research (RFBR) [19-34-70011]
- Russian Science Foundation [20-15-00395] Funding Source: Russian Science Foundation
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Understanding the hallmarks of the immune response to SARS-CoV-2 is critical for fighting the COVID-19 pandemic. We assessed antibody and T cell reactivity in convalescent COVID-19 patients and healthy donors sampled both prior to and during the pandemic. Healthy donors examined during the pandemic exhibited increased numbers of SARS-CoV-2-specific T cells, but no humoral response. Their probable exposure to the virus resulted in either asymptomatic infection without antibody secretion or activation of preexisting immunity. In convalescent patients, we observed a public and diverse T cell response to SARS-CoV-2 epitopes, revealing T cell receptor (TCR) motifs with germline-encoded features. Bulk CD4(+) and CD8(+) T cell responses to the spike protein were mediated by groups of homologous TCRs, some of them shared across multiple donors. Overall, our results demonstrate that the T cell response to SARS-CoV-2, including the identified set of TCRs, can serve as a useful biomarker for surveying antiviral immunity.
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