Journal
DIABETES CARE
Volume 39, Issue 11, Pages 2080-2088Publisher
AMER DIABETES ASSOC
DOI: 10.2337/dc16-0619
Keywords
-
Categories
Funding
- Medical Research Council [MR/L022699/1] Funding Source: researchfish
- MRC [MR/L022699/1] Funding Source: UKRI
Ask authors/readers for more resources
The reversible nature of early type 2 diabetes has been demonstrated in in vivo human studies. Recent in vivo and in vitro studies of beta-cell biology have established that the beta-cell loses differentiated characteristics, including glucose-mediated insulin secretion, under metabolic stress. Critically, the beta-cell dedifferentiation produced by long-term excess nutrient supply is reversible. Weight loss in humans permits restoration of first-phase insulin secretion associated with the return to normal of the elevated intrapancreatic triglyceride content. However, in type 2 diabetes of duration greater than 10 years, the cellular changes appear to pass a point of no return. This review summarizes the evidence that early type 2 diabetes can be regarded as a reversible beta-cell response to chronic positive calorie balance.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available