Journal
HELVETICA CHIMICA ACTA
Volume 104, Issue 1, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/hlca.202000217
Keywords
trifluoromethyl group; cycloaddition; aza-ortho-quinone methides; transition-metal free catalysis; indolines
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Funding
- JSPS KAKENHI [JP 18H02553]
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A stereoselective catalytic synthesis of 3-trifluoromethyl indolines was developed through the transition-metal-free [4+1] cycloaddition of benzoxazinones and sulfur ylides. The key to this catalytic transformation lies in the dual attack of sulfur ylides on substrates. This method is not only applicable to the synthesis of non-fluorinated indolines, but also achieved the synthesis of target products under stoichiometric conditions.
Stereoselective catalytic synthesis of 3-trifluoromethyl indolines through the [4+1] cycloaddition of benzoxazinones and sulfur ylides in a transition-metal-free manner was developed. In the presence of a catalytic amount of sodium hydride, aza-ortho-quinone methide intermediates were formed from trifluoromethyl benzoxazinones through decarboxylation after the first nucleophilic attack of sulfur ylides, which progressed to a second nucleophilic attack of sulfur ylides, resulting in the [4+1] cycloaddition. The key for this catalytic transformation is the dual attack of sulfur ylides on substrates. This unique transition-metal-free protocol is applicable to the synthesis of non-fluorinated vinyl-, ethynyl- or methyl-substituted indolines. The synthesis of 3-trifluoromethyl indoles was also achieved described under stoichiometric conditions.
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