Journal
DIABETES
Volume 66, Issue 2, Pages 418-425Publisher
AMER DIABETES ASSOC
DOI: 10.2337/db16-0680
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Funding
- Alberta Innovates Health Solutions
- Heart and Stroke Foundation of Canada
- Motyl Medical Sciences Graduate Studentship from the University of Alberta
- Genome Canada
- Canadian Institutes of Health Research (CIHR)
- CIHR
- Alberta Health Services
- Canadian Diabetes Association Scholar award
- CIHR New Investigator Salary Awards
- Natural Sciences and Engineering Research Council of Canada
- Canadian Diabetes Association
- Alberta Diabetes Institute
- Alberta Innovates [201600257, 201500030, 201400542] Funding Source: researchfish
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Oral administration of resveratrol is able to improve glucose homeostasis in obese individuals. Herein we show that resveratrol ingestion produces taxonomic and predicted functional changes in the gut microbiome of obese mice. In particular, changes in the gut microbiome were characterized by a decreased relative abundance of Turicibacteraceae, MonteHa, Lachnospiraceae, and Akkermansia and an increased relative abundance of Bacteroides and Para-bacteroides. Moreover, fecal transplantation from healthy resveratrol-fed donor mice is sufficient to improve glucose homeostasis in obese mice, suggesting that the resveratrol-mediated changes in the gut microbiome may play an important role in the mechanism of action of resveratrol.
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