Journal
GASTROENTEROLOGY
Volume 160, Issue 3, Pages 690-709Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.gastro.2020.09.058
Keywords
DNA; Methylation; Noncoding RNA; Chromatin; Histone; Colorectal Cancer; Esophageal Cancer; Gastric Cancer; Pancreatic Cancer; Barrett's Esophagus; Biomarkers; Diagnosis; Prognosis; Predictive; Treatment
Categories
Funding
- National Institutes of Health [P30CA15704, R01CA194663, RO1CA220004, RO1CA189184, U54CA143862, P01CA077852, R01CA207371, U01CA206110]
- R.A.C.E. Charities
- Cottrell Family Fund [UO1CA152756]
- Rodger Haggitt Endowed Chair
- Listwin Family Foundation
- Seattle Translational Tumor Research Program
- Fred Hutchinson Cancer Research Center
- National Cancer Institute [UO1CA152756, R50CA233042, P50CA150964]
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Colorectal cancer, liver cancer, stomach cancer, pancreatic cancer, and esophageal cancer are leading causes of cancer-related deaths worldwide. Gastrointestinal cancers are characterized by genomic and epigenomic DNA alterations. Epigenetic alterations have emerged as robust biomarkers for cancer screening and surveillance.
Colorectal cancer, liver cancer, stomach cancer, pancreatic cancer, and esophageal cancer are leading causes of cancer-related deaths worldwide. A fundamental trait of virtually all gastrointestinal cancers is genomic and epigenomic DNA alterations. Cancer cells acquire genetic and epigenetic alterations that drive the initiation and progression of the cancers by altering the molecular and cell biological processes of the cells. These alterations, as well as other host and microenvironment factors, ultimately mediate the clinical behavior of the precancers and cancers and can be used as biomarkers for cancer risk determination, early detection of cancer and precancer, determination of the prognosis of cancer and prediction of the response to therapy. Epigenetic alterations have emerged as one of most robust classes of biomarkers and are the basis for a growing number of clinical tests for cancer screening and surveillance.
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