Journal
GASTROENTEROLOGY
Volume 160, Issue 4, Pages 1041-1049Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.gastro.2020.12.068
Keywords
Early-Onset Colorectal Cancer; Epidemiology; Red Flags
Categories
Funding
- NCI [R01 CA196337, U24 CA 221936, K07 CA212057, 5F32 CA239360-02, 1UG3CA233314-01A1, 3 P30 CA023100, 1 R37 CA 222866-01]
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The rising incidence and mortality of early-onset colorectal cancer have prompted intense research into its epidemiology and characteristics. This review provides an update on early-onset CRC, focusing on epidemiology, molecular characterization, symptoms, and screening.
Rising trends in the incidence and mortality of early-onset colorectal cancer (CRC) in those who are younger than 50 years have been well established. These trends have spurred intense investigation focused on elucidating the epidemiology and characteristics of early-onset CRC, as well as on identifying strategies for early detection and prevention. In this review, we provide a contemporary update on early-onset CRC with a particular focus on epidemiology, molecular characterization, red flag signs and symptoms, and screening for early-onset CRC.
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