Tuning complexation of carboxymethyl cellulose/ cationic chitosan to stabilize Pickering emulsion for curcumin encapsulation

Carboxymethyl cellulose (CMC) is an economical and easily available cellulose derivative that ionizes in water and is used in several charge-related interfacial applications. However, compared with other chemically functionalized cellulose derivatives, such as cellulose nanocrystals, the development of CMC-based (CMC as the major ingredient) O/W emulsions remains unexplored. In this study, we synthesized a CMC and quaternized chitosan (QCS) complex for the preparation of Pickering emulsions. Partially protonated CMC was complexed with QCS, followed by neutralization at pH 7 to obtain the CMC/QCS (CQ) particles. The prepared CQ-stabilized emulsion showed a gel-like rheological behavior and exhibited emulsion stability against several environmental stresses, including pH, salt, temperature, and long-term storage. The curcumin was then encapsulated in the CQ-stabilized emulsion and displayed a reduced degradation rate. This study provides a new route for the development of a Pickering emulsion delivery system with improved stability, sustainability and reduced complexity.

Automated summary

This study successfully synthesized a new type of CMC/QCS (CQ) particles and encapsulated curcumin in the prepared CQ-stabilized emulsion, demonstrating good emulsion stability and reduced degradation rate against various environmental stresses.