Journal
FISH & SHELLFISH IMMUNOLOGY
Volume 107, Issue -, Pages 156-162Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fsi.2020.09.009
Keywords
IRF11; NF-kappa B; I kappa B alpha; Proteasomal degradation; Teleost fish
Funding
- National Key Research and Development Project [2018YFD0900503]
- National Nature Science Foundation of China [31822057]
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NF-kappa B is a typical transcription factor that regulates expression of various genes involved in inflammatory and immune responses. Therefore, it is essential that NF-kappa B signaling tightly regulated to maintain immune balance. Compared with those of mammals, the regulatory mechanisms of NF-kappa B signaling is rarely reported in teleost fish. I kappa B alpha is a prominent negative feedback regulator in the NF-kappa B signaling system. In this study, we determined that IRF11 enhances the inhibitory effect of I kappa B alpha on NF-kappa B activation in teleost fish. Overexpression of IRF11 can inhibit I kappa B alpha degradation, whereas its knockdown has the opposite effect of I kappa B alpha. Our study further indicates that I kappa B alpha was regulated via ubiquitin-proteasome degradation pathway, IRF11 inhibits I kappa B alpha in ubiquitin-proteasome degradation. This study provides a novel evidence on the regulation of innate immune signaling pathways in teleost fish and thus provides new insights into the regulatory mechanisms in mammals.
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