Journal
FEBS LETTERS
Volume 595, Issue 7, Pages 881-891Publisher
WILEY
DOI: 10.1002/1873-3468.14037
Keywords
Elf4; lysosomal biogenesis; macrophages; mTOR; Staphylococcus aureus
Funding
- Zhejiang Provincial Natural Science Foundation [LQ16H010004, LQ19C080001]
- Scientific Research Fund of Zhejiang Provincial Education Department [Y201432057]
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Elf4 is an important transcription factor induced by Staphylococcus aureus in macrophages, which enhances lysosomal function and increases the capacity of macrophages to eliminate intracellular pathogens.
Staphylococcus aureus is a major cause of infectious disease. Macrophages can directly destroy most of the invading bacteria through the phagolysosomal pathway. E74-like factor 4 (Elf4) is one of the important transcription factors that controls diverse pathogens, but the role of Elf4 in macrophage-mediated S. aureus eradication is unknown. Our data show that Elf4 is induced by S. aureus in macrophages. Elevated expression of Elf4 results in decreased bacterial load and inflammatory responses during S. aureus infection in vivo and in vitro. Elf4-overexpressed macrophages have decreased mTOR activity and increased lysosomal mass. Collectively, these results suggest that S. aureus induces Elf4 expression, which enhances lysosomal function and increases the capacity of macrophages to eliminate intracellular pathogens.
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