Journal
FEBS JOURNAL
Volume 288, Issue 21, Pages 6174-6186Publisher
WILEY
DOI: 10.1111/febs.15726
Keywords
immunotherapy resistance; innate immunity; TAM; TME; tumor immunotherapy
Categories
Funding
- National Natural Science Foundation of China [82073869]
- Guangdong Basic and Applied Basic Research Foundation [2019A050510019]
- Guangdong Provincial Key Laboratory of Construction Foundation [2017B030314030, 2020B1212060034]
- Guangzhou Science and Technology Planning Programme [202002020051]
- National Engineering Research Centre for New Drug and Druggability Evaluation, Seed Program of Guangdong Province [2017B090903004]
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Tumor-associated macrophages (TAMs) play essential roles in tumor progression and metastasis by promoting angiogenesis, immunosuppression, and fibrotic activities. While immunotherapy has shown promising results in eradicating cancer cells by activating the innate immune system, the tumor-suppressive environment is crucial in cancer relapse.
Tumor-associated macrophages (TAMs) are essential components of the tumor microenvironment involved in the progression and metastasis of cancer. They are intimately involved in angiogenesis and immunosuppression in normal and malignant tissues, as well as pro-fibrotic activities. With the development of immunotherapy, eradication of cancer cells through activation of the innate immune system has achieved inspiring results, whereas only a handful of patients show a durable response. The tumor-suppressive environment has been investigated with respect to playing a vital role in cancer relapse. In this review, we uncover the heterogeneity of the origin of TAMs, as well as the functions of TAMs in tumor progression associated with intricate regulatory networks in the tumor microenvironment, aiming to inspire therapeutic insight for tumor immunotherapy.
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