Journal
EXPERIMENTAL CELL RESEARCH
Volume 398, Issue 1, Pages -Publisher
ELSEVIER INC
DOI: 10.1016/j.yexcr.2020.112386
Keywords
Chromatin; Cold body; Nucleolus; Oocyte; Sperm; Xenopus
Categories
Funding
- National Institute of General Medical Sciences, National Institutes of Health [GM33397]
- MRC [MC_UU_12021/3, MC_U137788471] Funding Source: UKRI
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Novel spherical structures called C-bodies are induced by cold shock on lampbrush chromosomes of Xenopus laevis oocytes, showing symmetrical distribution on homologous LBCs similar to 5S rDNA pattern. Neither active transcription nor translation is required for their formation. The function of C-bodies remains unknown.
Here we describe novel spherical structures that are induced by cold shock on the lampbrush chromosomes (LBCs) of Xenopus laevis oocytes. We call these structures cold bodies or C-bodies. C-bodies are distributed symmetrically on homologous LBCs, with a pattern similar to that of 5S rDNA. Neither active transcription nor translation is necessary for their formation. Similar protrusions occur on the edges of some nucleoli. Endogenous LBCs as well as those derived from injected sperm form C-bodies under cold shock conditions. The function of C-bodies is unknown.
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