Microspheres of biomolecules/macromolecules for enantioseparation applications

This review summarizes the recent advances in the enantioselective separation of small molecules using biomolecules/macromolecules built up by natural inherent chiral moieties. Although different kinds of chiral selectors are known to date, the microspheres based on biomolecules have received paramount importance in view of their green synthesis, selective and sensitive separation of enantiomers from the racemic mixture. Direct separation of enantiomers devoid of using high-performance liquid chromatography adds to the elegance of this approach. We have covered the preparation of various biomolecules spheres by different methods. The enantiomeric separation of amino acids, drugs and other racemates and the underlying plausible mechanism is discussed.

Automated summary

This review highlights the recent progress in the enantioselective separation of small molecules using biomolecules/macromolecules with natural inherent chiral moieties, particularly focusing on the significance of biomolecule-based microspheres in terms of green synthesis, selective separation, and potential mechanism for enantiomeric separation of amino acids, drugs, and other racemates.