Journal
EUROPEAN JOURNAL OF RADIOLOGY
Volume 134, Issue -, Pages -Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ejrad.2020.109443
Keywords
Perfusion imaging; Pulmonary nodule; Subtraction CT; Dual-energy CT
Funding
- Canon Medical Systems Corporation
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Comparison between nodule enhancement on subtraction CT iodine maps and dual-energy CT iodine maps shows that subtraction CT is more effective in depicting iodine enhancement in pulmonary nodules, leading to improved visibility of nodules.
Objective: To compare nodule enhancement on subtraction CT iodine maps to that on dual-energy CT iodine maps using CT datasets acquired simultaneously. Methods: A previously-acquired set of lung subtraction and dual-energy CT maps consisting of thirty patients with 95 solid pulmonary nodules (>= 4 mm diameter) was used. Nodules were annotated and segmented on CT angiography, and mean nodule enhancement in the iodine maps calculated. Three radiologists scored nodule visibility with both techniques on a 4-point scale. Results: Mean nodule enhancement was higher (p < 0.001) at subtraction CT (34.9 +/- 12.9 HU) than at dualenergy CT (25.4 +/- 21.0 HU). Nodule enhancement at subtraction CT was judged more often to be highly visible for each observers (p < 0.001) with an area under the curve of 0.81. Conclusions: Subtraction CT is able to depict iodine enhancement in pulmonary nodules better than dual-energy CT.
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