Related references
Note: Only part of the references are listed.Natural compounds as potential adjuvants to cancer therapy: Preclinical evidence
Shian-Ren Lin et al.
BRITISH JOURNAL OF PHARMACOLOGY (2020)
Parthenolide inhibits ubiquitin-specific peptidase 7 (USP7), Wnt signaling, and colorectal cancer cell growth
Xue Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2020)
Repurposing of auranofin: Thioredoxin reductase remains a primary target of the drug
Xiaonan Zhang et al.
BIOCHIMIE (2019)
Identification of thiostrepton as a pharmacological approach to rescue misfolded alpha-sarcoglycan mutant proteins from degradation
Lucile Hoch et al.
SCIENTIFIC REPORTS (2019)
Cytotoxic unsaturated electrophilic compounds commonly target the ubiquitin proteasome system
Karthik Selvaraju et al.
SCIENTIFIC REPORTS (2019)
Parthenolide Covalently Targets and Inhibits Focal Adhesion Kinase in Breast Cancer Cells
Charles A. Berdan et al.
CELL CHEMICAL BIOLOGY (2019)
Management of relapsed and refractory multiple myeloma: novel agents, antibodies, immunotherapies and beyond
C. S. Chim et al.
LEUKEMIA (2018)
L1000FWD: fireworks visualization of drug-induced transcriptomic signatures
Zichen Wang et al.
BIOINFORMATICS (2018)
Targeted cancer therapy through 17-DMAG as an Hsp90 inhibitor: Overview and current state of the art
Hassan Mellatyar et al.
BIOMEDICINE & PHARMACOTHERAPY (2018)
Pharmacological inhibition of DUSP6 suppresses gastric cancer growth and metastasis and overcomes cisplatin resistance
Qi-Nian Wu et al.
CANCER LETTERS (2018)
Ancient drug curcumin impedes 26S proteasome activity by direct inhibition of dual-specificity tyrosine-regulated kinase 2
Sourav Banerjee et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Manumycin A Is a Potent Inhibitor of Mammalian Thioredoxin Reductase-1 (TrxR-1)
Anupama Tuladhar et al.
ACS MEDICINAL CHEMISTRY LETTERS (2018)
Cancer cell plasticity: Impact on tumor progression and therapy response
Victoria da Silva-Diz et al.
SEMINARS IN CANCER BIOLOGY (2018)
Bioactivities of EF24, a Novel Curcumin Analog: A Review
Yonghan He et al.
FRONTIERS IN ONCOLOGY (2018)
Data Resources for the Computer-Guided Discovery of Bioactive Natural Products
Ya Chen et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2017)
The Essential Medicinal Chemistry of Curcumin
Kathryn M. Nelson et al.
JOURNAL OF MEDICINAL CHEMISTRY (2017)
Clustergrammer, a web-based heatmap visualization and analysis tool for high-dimensional biological data
Nicolas F. Fernandez et al.
SCIENTIFIC DATA (2017)
Hsp72 Is an Intracellular Target of the α,β-Unsaturated Sesquiterpene Lactone, Parthenolide
Myungsun Shin et al.
ACS OMEGA (2017)
A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles
Aravind Subramanian et al.
CELL (2017)
Deubiquitinases and cancer: A snapshot
Nishant Singh et al.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2016)
Resistance mechanisms after tyrosine kinase inhibitors afatinib and crizotinib in non-small cell lung cancer, a review of the literature
A. J. van der Wekken et al.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2016)
Feeling Nature's PAINS: Natural Products, Natural Product Drugs, and Pan Assay Interference Compounds (PAINS)
Jonathan B. Baell
JOURNAL OF NATURAL PRODUCTS (2016)
Counting on natural products for drug design
Tiago Rodrigues et al.
NATURE CHEMISTRY (2016)
Molecular targets of curcumin for cancer therapy: an updated review
Pandima Devi Kasi et al.
TUMOR BIOLOGY (2016)
Badapple: promiscuity patterns from noisy evidence
Jeremy J. Yang et al.
JOURNAL OF CHEMINFORMATICS (2016)
The isopeptidase inhibitor 2cPE triggers proteotoxic stress and ATM activation in chronic lymphocytic leukemia cells
Andrea Tomasella et al.
ONCOTARGET (2016)
Withaferin A Analogs That Target the AAA plus Chaperone p97
Shasha Tao et al.
ACS CHEMICAL BIOLOGY (2015)
Cheminformatic comparison of approved drugs from natural product versus synthetic origins
Christopher F. Stratton et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2015)
Curcumin: A Natural Lead for Potential New Drug Candidates
Ana Sofia Oliveira et al.
CURRENT MEDICINAL CHEMISTRY (2015)
The natural tumorcide Manumycin-A targets protein phosphatase 1α and reduces hydrogen peroxide to induce lymphoma apoptosis
Gregory B. Carey et al.
EXPERIMENTAL CELL RESEARCH (2015)
Induction of heat shock protein HSPA6 (HSP70B′) upon HSP90 inhibition in cancer cell lines
Petric Kuballa et al.
FEBS LETTERS (2015)
Thiostrepton interacts covalently with Rpt subunits of the 19S proteasome and proteasome substrates
Cristinel Sandu et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2015)
Identification and characterization of essential genes in the human genome
Tim Wang et al.
SCIENCE (2015)
Induction of Tumor Cell Apoptosis by a Proteasome Deubiquitinase Inhibitor Is Associated with Oxidative Stress
Slavica Brnjic et al.
ANTIOXIDANTS & REDOX SIGNALING (2014)
Small-Molecule RA-9 Inhibits Proteasome-Associated DUBs and Ovarian Cancer In Vitro and In Vivo via Exacerbating Unfolded Protein Responses
Kathleen Coughlin et al.
CLINICAL CANCER RESEARCH (2014)
Targeting Proteasomal Pathways by Dietary Curcumin for Cancer Prevention and Treatment
Noor Hasima et al.
CURRENT MEDICINAL CHEMISTRY (2014)
Survival of mycobacteria depends on proteasome-mediated amino acid recycling under nutrient limitation
Yifat Elharar et al.
EMBO JOURNAL (2014)
Polypharmacology: Challenges and Opportunities in Drug Discovery
Andrew Anighoro et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Clinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growth
Ningning Liu et al.
ONCOTARGET (2014)
Targeting Aberrant Glutathione Metabolism to Eradicate Human Acute Myelogenous Leukemia Cells
Shanshan Pei et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Deubiquitinase Inhibition of 19S Regulatory Particles by 4-Arylidene Curcumin Analog AC17 Causes NF-kappa B Inhibition and p53 Reactivation in Human Lung Cancer Cells
Binhua Zhou et al.
MOLECULAR CANCER THERAPEUTICS (2013)
Non-Specific Protein Modifications by a Phytochemical Induce Heat Shock Response for Self-Defense
Kohta Ohnishi et al.
PLOS ONE (2013)
Manumycin A inhibits triple-negative breast cancer growth through LC3-mediated cytoplasmic vacuolation death
P. K. Singha et al.
CELL DEATH & DISEASE (2013)
Using the Heat-Shock Response To Discover Anticancer Compounds that Target Protein Homeostasis
Sandro Santagata et al.
ACS CHEMICAL BIOLOGY (2012)
Cancer Vulnerabilities Unveiled by Genomic Loss
Deepak Nijhawan et al.
CELL (2012)
Failure of Amino Acid Homeostasis Causes Cell Death following Proteasome Inhibition
Amila Suraweera et al.
MOLECULAR CELL (2012)
Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs
Drew J. Adams et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Natural products: An evolving role in future drug discovery
Bhuwan B. Mishra et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2011)
Dissecting Therapeutic Resistance to RAF Inhibition in Melanoma by Tumor Genomic Profiling
Nikhil Wagle et al.
JOURNAL OF CLINICAL ONCOLOGY (2011)
Multitargeting by curcumin as revealed by molecular interaction studies
Subash C. Gupta et al.
NATURAL PRODUCT REPORTS (2011)
Inhibition of proteasome deubiquitinating activity as a new cancer therapy
Padraig D'Arcy et al.
NATURE MEDICINE (2011)
Cancer cell death induced by phosphine gold(I) compounds targeting thioredoxin reductase
Valentina Gandin et al.
BIOCHEMICAL PHARMACOLOGY (2010)
Heat shock protein 90 inhibitors attenuate inflammatory responses in atherosclerosis
Julio Madrigal-Matute et al.
CARDIOVASCULAR RESEARCH (2010)
New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays
Jonathan B. Baell et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
Ansamycin Inhibitors of Hsp90: Nature's Prototype for Anti-Chaperone Therapy
James R. Porter et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2009)
Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages
Gabriela Molina et al.
NATURE CHEMICAL BIOLOGY (2009)
Breaking the chains: structure and function of the deubiquitinases
David Komander et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)
Curcumin: From ancient medicine to current clinical trials
H. Hatcher et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2008)
Induction of heme oxygenase-1 by cobalt protoporphyrin enhances the antitumour effect of bortezomib in adult T-cell leukaemia cells
R. S. Hamamura et al.
BRITISH JOURNAL OF CANCER (2007)
Mass spectrometric characterization of the affinity-purified human 26S proteasome complex
Xiaorong Wang et al.
BIOCHEMISTRY (2007)
Extensive immunoglobulin production sensitizes myeloma cells for proteasome inhibition
Silke Meister et al.
CANCER RESEARCH (2007)
The tumor proteasome is a primary target for the natural anticancer compound withaferin a isolated from Indian Winter Cherry
Huanjie Yang et al.
MOLECULAR PHARMACOLOGY (2007)
Functions of the proteasome: from protein degradation and immune surveillance to cancer therapy
A. L. Goldberg
BIOCHEMICAL SOCIETY TRANSACTIONS (2007)
Cdc48 (p97): a 'molecular gearbox' in the ubiquitin pathway?
Stefan Jentsch et al.
TRENDS IN BIOCHEMICAL SCIENCES (2007)
Innovation - The Connectivity Map: a new tool for biomedical research
Justin Lamb
NATURE REVIEWS CANCER (2007)
The connectivity map: Using gene-expression signatures to connect small molecules, genes, and disease
Justin Lamb et al.
SCIENCE (2006)
Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis
Emanuela Aleo et al.
CANCER RESEARCH (2006)
Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells
Esther A. Obeng et al.
BLOOD (2006)
Celastrol, a triterpene extracted from the Chinese Thunder of God Vine, is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice
Huanjie Yang et al.
CANCER RESEARCH (2006)
Inhibition of proteasome activity, nuclear factor-KB translocation and cell survival by the antialcoholism drug disulfiram
H Lövborg et al.
INTERNATIONAL JOURNAL OF CANCER (2006)
Endoplasmic reticulum stress compromises the ubiquitin-proteasome system
V Menéndez-Benito et al.
HUMAN MOLECULAR GENETICS (2005)
ESOL: Estimating aqueous solubility directly from molecular structure
JS Delaney
JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES (2004)
Discovery, characterization and SAR of gambogic acid as a potent apoptosis inducer by a HTS assay
HZ Zhang et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2004)
Proteasome inhibitor PS-341 induces a apoptosis through induction of endoplasmic reticulum stress-reactive oxygen species in head and neck squamous cell carcinoma cells
A Fribley et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Linking the growth inhibition response from the National Cancer Institute's anticancer screen to gene expression levels and other molecular target data
A Wallqvist et al.
BIOINFORMATICS (2003)
Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome
S Uhle et al.
EMBO JOURNAL (2003)
Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs
MV Blagosklonny
LEUKEMIA (2002)
Pharmacological profiles of a novel opioid receptor-like1 (ORL1) receptor antagonist, JTC-801
H Yamada et al.
BRITISH JOURNAL OF PHARMACOLOGY (2002)
Share Paper
