Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2021, Issue 6, Pages 998-1002Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.202001561
Keywords
Convergent domino cyclization; Iodine; Methyl azaarenes; 2-Quinoline-4,5-diaryl-oxazole
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Funding
- National Natural Science Foundation of China [21702091]
- Science and Technology Innovation Development Plan of Yantai [2020MSGY114]
- Yantai Double Hundred Plan
- Graduate Innovation Foundation of Yantai University [YDZD2035]
- College Students Innovation and Entrepreneurship Training Program [S202011066007]
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An oxidative [3+1+1] convergent domino cyclization method was developed for the efficient synthesis of various 2,4,5-trisubstituted oxazoles. This method features a wide substrate scope, mild reaction conditions, and easy availability of substrates.
An oxidative [3+1+1] convergent domino cyclization is disclosed. This protocol enables to get quinoline, quinoxaline, quinazolin-4(3H)-one and benzo[d]thiazole attached 2,4,5-trisubstituted oxazoles from methyl azaarenes, benzoins, and NH4OAc in the presence of iodine and molecular sieves without any metal catalyst. The reaction features wide substrate scope, good functional group tolerance, mild reaction conditions, and easily available substrates.
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