Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2021, Issue 8, Pages 1286-1289Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.202001633
Keywords
Cannabidibutol; Cannabidiol; Cannabidivarin; Flow chemistry; Friedel-Crafts reaction
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Funding
- University of Camerino (FAR program)
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This study presents the first continuous flow chemical synthesis of cannabidiol (CBD) and its analogues, achieving high yields and limiting the formation of psychoactive and illegal cannabinoids.
Cannabidiol is one of the main non-psychoactive cannabinoids present in Cannabis sativa and, in the last decade, it is gaining great interest among the scientific community for its pharmaceutical, nutraceutical, and cosmetic applications. Herein, we report the first continuous flow chemical synthesis of cannabidiol (CBD) and its analogues cannabidivarin (CBDV) and cannabidibutol (CBDB). This approach permits to synthesize products in very good yields (55-59 %), limiting the formation of psychoactive and illegal cannabinoids such as tetrahydrocannabinol (THC).
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