Silver-Catalyzed Acyl Nitrene Transfer Reactions Involving Dioxazolones: Direct Assembly of N-Acylureas

Dioxazolones and isocyanides are useful synthetic building blocks, and have attracted significant attention from researchers. However, the silver-catalyzed nitrene transfer reaction of dioxazolones has not been investigated to date. Herein, a silver-catalyzed acyl nitrene transfer reaction involving dioxazolones, isocyanides, and water was realized in the presence of Ag2O to afford a series of N-acylureas in moderate to good yields.

Automated summary

A silver-catalyzed acyl nitrene transfer reaction involving dioxazolones, isocyanides, and water was successfully achieved in this study, leading to the synthesis of a series of N-acylureas in moderate to good yields. This provides a new research direction for the application of dioxazolones and isocyanides in synthetic chemistry.