Journal
EUROPEAN JOURNAL OF OPHTHALMOLOGY
Volume 31, Issue 6, Pages 3463-3470Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1120672120977824
Keywords
Optic neuropathy; neuro ophthalmology; optic neuritis; open angle glaucoma; glaucoma; orbital trauma; orbital disease; neuro-ophthalmic disease; pediatric ophthalmology
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The study investigated the safety and efficacy of suprachoroidal umbilical cord-derived MSCs (UC-MSCs) implantation in patients with optic atrophy. Significant improvements in BCVA and VF results were observed during the 12-month follow-up. However, there was no significant difference in the mean RNFL thickness measurements between baseline and 12 months.
Background: Optic nerve cells can be irreversibly damaged by common various causes. Unfortunately optic nerve and retinal ganglion cells have no regenerative capacity and undergo apoptosis in case of damage. In this study, our aim is to investigate the safety and efficacy of suprachoroidal umbilical cord-derived MSCs (UC-MSCs) implantation in patients with optic atrophy. Methods: This study enrolled 29 eyes of 23 patients with optic atrophy who were followed in the ophthalmology department of our hospital. BCVA, anterior segment, fundus examination, color photography, and optical coherence tomography (OCT) were carried out at each visit. Fundus fluorescein angiography and visual field examination were performed at the end of the first, third, sixth months, and 1 year follow-up. Results: After suprachoroidal UC-MSCs implantation there were statistically significant improvements in BCVA and VF results during 12 months follow-up (p < 0.05). When we evaluate the results of VF tests, the mean deviation (MD) value at baseline was -26.11 +/- 8.36 (range -14.18 to -34.41). At the end of the first year it improved to -25.01 +/- 8.73 (range -12.56 to -34.41) which was statistically significant (p < 0.05). When we evaluate the mean RNFL thickness measurements at baseline and at 12 month follow-up the results were 81.8 +/- 24.9 mu m and 76.6 +/- 22.6 mu m, respectively. There was not a significant difference between the mean values (p > 0.05). Conclusion: Stem cell treatment with suprachoroidal implantation of UCMSCs seems to be safe and effective in the treatment for optic nerve diseases that currently have no curative treatment options
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