Journal
EUROPEAN JOURNAL OF NEUROSCIENCE
Volume 55, Issue 11-12, Pages 3303-3323Publisher
WILEY
DOI: 10.1111/ejn.15059
Keywords
ageing; Alzheimer' s disease; dementia; Gamma stimulation; music‐ based interventions; neural oscillations
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Funding
- NSF-STTR
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Music-based interventions have gained popularity as a non-invasive and sustainable form of care for dementia-related disorders. However, the evidence regarding their efficacy is mixed. Recent research has explored the clinical impact of non-invasive Gamma-frequency sensory stimulation on dementia, showing promising results. Combining Gamma-frequency stimulation with music-based interventions may enhance their therapeutic power.
In recent years, music-based interventions (MBIs) have risen in popularity as a non-invasive, sustainable form of care for treating dementia-related disorders, such as Mild Cognitive Impairment (MCI) and Alzheimer's disease (AD). Despite their clinical potential, evidence regarding the efficacy of MBIs on patient outcomes is mixed. Recently, a line of related research has begun to investigate the clinical impact of non-invasive Gamma-frequency (e.g., 40 Hz) sensory stimulation on dementia. Current work, using non-human-animal models of AD, suggests that non-invasive Gamma-frequency stimulation can remediate multiple pathophysiologies of dementia at the molecular, cellular and neural-systems scales, and, importantly, improve cognitive functioning. These findings suggest that the efficacy of MBIs could, in theory, be enhanced by incorporating Gamma-frequency stimulation into current MBI protocols. In the current review, we propose a novel clinical framework for non-invasively treating dementia-related disorders that combines previous MBIs with current approaches employing Gamma-frequency sensory stimulation. We theorize that combining MBIs with Gamma-frequency stimulation could increase the therapeutic power of MBIs by simultaneously targeting multiple biomarkers of dementia, restoring neural activity that underlies learning and memory (e.g., Gamma-frequency neural activity, Theta-Gamma coupling), and actively engaging auditory and reward networks in the brain to promote behavioural change.
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