Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 208, Issue -, Pages -Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2020.112791
Keywords
Siderophore; Hydroxamate; Trojan horse; Siderophore-drug conjugate; Fe (III) binding affinity; Sideromycins
Categories
Funding
- National Research Foundation (NRF) [105892, 120386]
- University of KwaZulu-Natal (South Africa)
- Marato TV3 foundation 2018 [20183530]
Ask authors/readers for more resources
Hydroxamic acids are an important class of molecules, in particular because of their metal-chelating ability. Microorganisms, including pathogenic bacteria, use hydroxamate-based entities (siderophores), among others, to acquire Fe (III). The Trojan horse strategy exploits the need of bacteria for this metal by using Fe (III) active transporters to carry antibacterial or bactericidal moieties into the bacterial cell. Many natural Trojan horses (sideromycins) are derived from hydroxamic acids, thereby reflecting their potency. Various artificial sideromycins and their antibacterial activities have been reported. This review discusses the structural aspects of the hydroxamate-siderophores isolated in the last two decades, the chemical synthesis of their building blocks, their binding affinity towards Fe (III), and their application as Trojan horses (weaknesses and strengths). (c) 2020 Elsevier Masson SAS. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available