Journal
EUROPEAN JOURNAL OF HAEMATOLOGY
Volume 106, Issue 3, Pages 417-424Publisher
WILEY
DOI: 10.1111/ejh.13567
Keywords
acute graft‐ versus‐ host disease; allogeneic hematopoietic cell transplantation; vitamin E
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Funding
- Handelsgartner Ove William Buhl Olesen og aegtefaelle fru Edith Buhl Olesen's Mindelegat
- Karen A. Tolstrups Fond
- Froken Amalie Jorgensens Mindelegat
- Grosserer Valdemar Foersom og Hustru Thyra Foersoms Fond
- Tomrermester Jorgen Holm og Hustru Elisa f. Hansens Mindelegat
- Danish National Research Foundation [DNRF126]
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The study found that higher pre-transplantation vitamin E levels were associated with a lower risk of developing grade II-IV acute GvHD. However, post-transplantation vitamin E levels were not predictive of subsequent acute GvHD.
Objectives Vitamin E has antioxidant and immunomodulatory effects that might influence the development of acute graft-versus-host disease (GvHD). We investigated the association between plasma vitamin E levels and acute GvHD. Methods We studied 115 adults who underwent myeloablative allogeneic hematopoietic cell transplantation between July 2015 and August 2018. Vitamin E was measured by high-performance liquid chromatography in stored plasma samples obtained pre-transplantation at day -23 (+/- 15 days) and post-transplantation at day +28 (+/- 3 days). Results Pre-transplantation vitamin E levels were inversely associated with grade II-IV acute GvHD (hazard ratio 0.68 per 10 mu mol/L increase, 95% confidence interval [CI]: 0.47-0.98). The association remained after adjustment for known prognostic factors for acute GvHD. Patients with levels below the median had a cumulative incidence of grade II-IV acute GvHD of 46% (CI: 33-59%) versus 21% (CI: 10-32%) in patients with levels above the median. No clear association with non-relapse mortality, relapse, or chronic GvHD was found. Post-transplantation vitamin E levels (measured in 72 [63%] patients) were correlated with pre-transplantation levels (rho = .31) but were not associated with subsequent grade II-IV acute GvHD. Conclusions High pre-transplantation vitamin E levels were associated with less acute GvHD.
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