Journal
DEVELOPMENTAL CELL
Volume 39, Issue 3, Pages 289-301Publisher
CELL PRESS
DOI: 10.1016/j.devcel.2016.10.002
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Funding
- DKFZ Light Microscopy Facility
- DKFZ Genomics and Proteomics Core Facility
- German Cancer Research Center (DKFZ)
- National Center for Tumor Diseases Heidelberg (NCT, IFP IV)
- German Research Foundation (DFG) [SFB 873]
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Acinar cells make up the majority of all cells in the pancreas, yet the source of new acinar cells during homeostasis remains unknown. Using multicolor lineage-tracing and organoid-formation assays, we identified the presence of a progenitor-like acinar cell subpopulation. These cells have long-term self-renewal capacity, albeit in a unipotent fashion. We further demonstrate that binuclear acinar cells are terminally differentiated acinar cells. Transcriptome analysis of single acinar cells revealed the existence of a minor population of cells expressing progenitor markers. Interestingly, a gain of the identified markers accompanied by a transient gain of proliferation was observed following chemically induced pancreatitis. Altogether, our study identifies a functionally and molecularly distinct acinar subpopulation and thus transforms our understanding of the acinar cell compartment as a pool of equipotent secretory cells.
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