Journal
EUROPEAN JOURNAL OF DERMATOLOGY
Volume 30, Issue 6, Pages 655-662Publisher
JOHN LIBBEY EUROTEXT LTD
DOI: 10.1684/ejd.2020.3930
Keywords
autophagy; autophagy-related regulators; melanocytes; melanogenesis; melanosome; skin pigment diseases
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Funding
- National Natural Science Foundation of China [81671924, 81272105]
- National Key Research and Development Plan of China [2017YFC1103301]
- Health and Medical Treatment Collaborative Innovation Major Special Projects of Guangzhou [201508020253]
- Science and Technology Key Project of Guangdong Province [2014B020212010]
- Science and Technology Planning Project of Guangdong Province of China [2015B020233012]
- Military Medical Innovation Special Projects [18CXZ029]
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Hyperpigmentation and hypopigmentation are two manifestations of skin pigmentation diseases. Recent studies have shown that autophagy is involved in the development of skin pigmentation diseases. The melanosome is a lysosome-related organelle characterized by the production of melanin. The autophagosome-lysosome degradation pathway exhibits a characteristic cell renewal function. The functions of melanosomes and autophagosomes intersect and the vesicle transport pathway mediates both autophagosome and melanosome formation, which may involve different regulatory protein complexes. Current studies have revealed that several autophagy-related regulators of autophagosome formation are involved in melanosome formation and maturation and also regulate melanogenesis, and that melanosomes can be degraded via autophagy in melanocytes. Autophagy is also involved in regulating the living environment of melanocytes. Understanding the effects of autophagy on pigmentation may support our understanding of pigmentation diseases. This article reviews the relationship between autophagy and pigmentation in melanocytes.
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