Journal
DEVELOPMENTAL CELL
Volume 39, Issue 2, Pages 139-153Publisher
CELL PRESS
DOI: 10.1016/j.devcel.2016.09.030
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Funding
- Agence Nationale de la Recherche [ANR-13-BSV2-0013]
- Fondation pour la Recherche Medicale [DEQ20150934717]
- CNRS, France
- Agence Nationale de la Recherche (ANR) [ANR-13-BSV2-0013] Funding Source: Agence Nationale de la Recherche (ANR)
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An evolutionarily conserved feature of cellular organelles is the distinct phospholipid composition of their bounding membranes, which is essential to their identity and function. Within eukaryotic cells, two major lipid territories can be discerned, one centered on the endoplasmic reticulum and characterized by membranes with lipid packing defects, the other comprising plasma-membrane-derived organelles and characterized by membrane charge. We discuss how this cellular lipid organization is maintained, how lipid flux is regulated, and how perturbations in cellular lipid homeostasis can lead to disease.
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