Journal
DEVELOPMENTAL CELL
Volume 38, Issue 6, Pages 621-634Publisher
CELL PRESS
DOI: 10.1016/j.devcel.2016.08.012
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Funding
- Medical Research Council [MR/N009371/1] Funding Source: Medline
- MRC [MR/N009371/1] Funding Source: UKRI
- Medical Research Council [MR/N009371/1, 1417849] Funding Source: researchfish
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Cell competition is a cell fitness-sensing mechanism conserved from insects to mammals that eliminates those cells that, although viable, are less fit than their neighbors. An important implication of cell competition is that cellular fitness is not only a cell-intrinsic property but is also determined relative to the fitness of neighboring cells: a cell that is of suboptimal fitness in one context may be super-fit in the context of a different cell population. Here we discuss the mechanisms by which cell competition measures and communicates cell fitness levels and the implications of this mechanism for development, regeneration, and tumor progression.
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